Software Tools available for Biologists If you are a biologist who has heard of CambridgeSoft, you probably know that we offer products such as ChemDraw – a highly evolved tool for chemical drawing. You may not know that we also make a suite of tools for biologists. CambridgeSoft has created software for biologists to accomplish the following: Import images and data into an electronic lab notebook Search through and share experimental data electronically via this same notebook Draw biological pathway diagrams and plasmid maps for papers or web pages Help organize and store media, Eppi® tubes, buffers, samples, reagents and other lab paraphernalia Store and automatically interpret assay data Compare small molecule properties on a visual dashboard Biology Electronic Notebook One of the biggest advantages of the CambridgeSoft electronic notebook is its ability to replace the process of taping images or graphs into your notebook with an easy electronic file import/cut and paste system. Another is the ability to quickly search your notebooks to find data on past experiments. BioAssay CambridgeSoft’s BioAssay program gives an alternative to this process. The biologist is able to design an experiment protocol using a wizard. This protocol defines the plate setup, dilution factors and control wells and is flexible enough to accommodate whatever unique plate setup fits the experiment. The biologist also indicates what should happen with the data after import, which might include many different calculations. Finally, the user is able to visualize this output in a way that makes most sense. In some cases, this visualization might be a series of graphs or a heat map. These images and data can then be imported into your electronic lab notebook, if you like. These tools, and more, can be installed on your computer just as any other desktop software can. They work off a Microsoft SQL server that runs easily in the background as an individual instance. And, if your lab wants to share data or information (such as electronic lab notebook entries or inventory information) across multiple users, we offer an easy upgrade from the desktop software to our workgroup product. Read about more Software Tools for Biologists or Register for a Tools for Biologists webinar   Announcing the new CambridgeSoft User Forum CambridgeSoft has offered our user community a location to resolve technical issues, find answers to frequently asked questions, and download manuals and patches since 1994, when our Support web site was first launched. In 1999, our Support web site was recognized by the Association of Support Professionals (ASP) as one of the Top 10 Best Support web sites. Our goal is to continue that tradition of excellence for the CambridgeSoft community. Our first step in meeting that goal is to offer a means by which our users can share their experiences with other CambridgeSoft users. CambridgeSoft Support staff will be monitoring these forums and responding to posts. Although the Forum is integrated with our Support site and CambridgeSoft Support staff will be monitoring it, we still encourage that users contact Support via email to create Support tickets that can be assigned and tracked for resolution. Our hope is that the new CambridgeSoft Customer Forum will increase productivity. We also hope that the Forum will be a meeting ground where users help users, and share ideas and information. The User Forum is an exciting first step towards continuing our web site excellence. Stay tuned for announcements on additional improvements to the site coming soon. Read the full User Forum article or Visit the User Forum website   Finding Better Leads using Molecular Fields 2D drawings are a ubiquitous representation for molecular structures. Despite this, they provide only a limited insight into the activity and molecular properties of a compound. Cresset's Field based representations provide much more accurate descriptions of a compound's shape and binding interactions. Fields can be used throughout the drug discovery and development process from escaping the chemotype trap in lead optimization to defining optimal patent protection strategies. While we all are trained to instantly recognise and think about compounds in 2D structure terms, we do not often consider how much insight they really give us into the properties and activities of our molecules. We use our experience to guide our decisions, but we are constantly aware that we cannot always accurately predict the impact that even small changes to a 2D structure will have on important molecular properties such as ADME, toxicity and activity. Cresset has developed a number of Field based products to model, analyze and compare the fields of molecules. These products, which are available as easy-to-use Windows PC packages, allow the user to align molecules using fields, shape or a combination of the two. FieldTemplaterTM — Creates a model of the 3D bioactive conformation of active molecules. This requires input of 2 or more active ligands drawn in 2D. It works by identifying multiple conformations for each molecule and searches for a common field pattern across the various conformations of the different molecules. FieldAlignTM — Once you know the bioactive conformation of a single molecule or group of molecules, FieldAlignTM allows you to align any molecule drawn in 2D to this 3D template and calculate a field similarity value. In this way you can compare other actives or unknowns to your activity template and see how the field pattern changes and which field points are conserved in actives. Read the full Molecular Fields article or Download a free month trial of FieldAlign   Reviewers solicited     We are in search of reviewers to put CambridgeSoft products to the test. Of particular interest to us are comments on our newest release of ChemBIoFinder, BioOffice, BioDraw, BioAssay, BioViz, Inventory, E-Notebook, and ChemACX. If you are up to the challenge, please contact our reviews department at reviews@cambridgesoft.com. Approved applicants will be eligible to receive free software in order to write the review. In addition, you will receive a free t-shirt if your story appears online or in print. Apply by email to reviews@cambridgesoft.com   You can change your language preference (English, French, German, Japanese), or any of Manage your account You can offer content for future ChemBioNews, or remove yourself from our list, by writing to the ChemBioNews editor, Jesse Gordon, at jesse.gordon@cambridgeSoft .com CambridgeSoft Corporation 100 CambridgePark Drive Cambridge, MA 02140 USA US Tel: 1 800 315-7300 / 1 617 588-9300 EU Tel: 00 800 875 20000 / +44 1223 464990 JP Tel: 0120-146-700 / 03-3502-7800 CBN 19.1.6, ISSN 1932-1023 © 2009 All Rights Reserved www.ChemBioNews.com

Upcoming Events   April 1st: Webinar: Custom Templates April 8th: Webinar: Tools for Biologists April 22ndWebinar: ChemDraw's Variable Attaachment April 29th: Webinar: BioAssay Protocols June 17th: CambridgeSoft Tokyo Seminar 2009 Please click here for list of other upcoming events CambridgeSoft ChemBioClips ChemBioClip #21: "Drawing Plasmid Maps" ChemBioClips are one minute feature presentations. Did you know... ...that your copy of ChemBioDraw Ultra allows you to easily draw plasmid maps? Just click-and-play: Flash Tech Notes Question: When I try to run a MOPAC minimization, I get the following error: output file doesn't exist! error: Cannot locate output file! Click here for the answer.   White Papers White Paper #8: "Query Capabilities of Chem & Bio Draw 11.0" In this white paper, we examine how ChemDraw and ISIS/Draw applications may be used to draw query structures, one of the most powerful, yet perhaps least understood features of these applications. Click here to read more Email Contacts Desktop Software software@cambridgesoft.com Enterprise Solutions solutions@cambridgesoft.com Scientific Databases databases@cambridgesoft.com     Telephone Contacts America 1 800 315-7300 1 617-588-9300 Europe 00 800 875 20000 +44 1223 464990 Pacific 0120-146-700 03-3502-7800